Children’s Histazine Syrup 24-Hour – Allergy Relief

Each 5 ml of Histazine syrup contains: 5 mg Cetirizine. Histazine syrup is not intended for children and infants below 2 years of age.

WHAT IS HISTAZINE SYRUP INTENDED FOR? 

An antihistaminic preparation for the treatment of allergic effects. For the treatment of seasonal and perennial allergic rhinitis and allergic skin effects in children aged 2 years and over.

HISTAZINE-1 0.1% SYRUP
HISTAZINE-1 0.1% SYRUP

Histazine Syrup- FAQ

What is Histazine used for? Cetirizine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Ref: 1.

Is Histazine good for coughing? Yes, a smaller study involving 20 school-age children found that cetirizine (Histazine) clinically improves cough due to pollen allergy. In that study, the antihistamine was significantly more effective than placebos in reducing chronic cough in children with allergies.Ref:3.

Will Histazine make my child sleepy? Most children generally respond well to Histazine. Few children have to stop taking it because of side effects. The most common side effect of Histazine is drowsiness. If other side effects occur, they are usually mild to moderate. Ref: 4.

Can a 1 year old take Histazine? Yes, the dose should be adjusted by your doctor.Be sure to avoid giving your child more than the maximum dosage listed on the package. To find out how much and how long your child can take these drugs safely, talk with your child’s doctor.Ref: 5

Is it better to take Histazine at night or in the morning? Cetirizine( Histazine) can be taken at any time of the day. In most people it is non-sedating, so they take it in the morning. However, a percentage of people do find it to be sedating so if it does make you drowsy it is best to take it in the evening. Histazine can be taken with or without food.Ref: 6.

Is Histazine safe for babies?

  • Children 6 to 11 Years: The recommended initial dose of Histazine in children aged 6 to
  • 11 years is 5 or 10 mg (1 or 2 teaspoons) once daily depending on symptom severity. The time of administration may be varied to suit individual patient needs.
  • Children 2 to 5 Years: The recommended initial dose of Histazine syrup in children aged 2 to 5 years is 2.5 mg (½ teaspoon) once daily. The dosage in this age group can be increased to a maximum dose of 5 mg per day given as 1 teaspoon (5 mg) once daily, or as ½ teaspoon (2.5 mg) given every 12 hours.
  • Children 6 months to < 2 years: The recommended dose of Histazine syrup in children 6 months to 23 months of age is 2.5 mg (½ teaspoon) once daily.The dose in children 12 to 23 months of age can be increased to a maximum dose of 5 mg per day, given as ½ teaspoonful (2.5 mg) every 12 hours.Ref: 2.

Histazine syrup- Dosage

  • Children 2 to 6 years of age: 2.5 ml once daily. A dosage of up to 5 ml once daily or 2.5 ml twice daily can be used. 
  • Children above 6 years of age and adults: 10 ml once daily or 5 ml twice daily.

N.B.: If the symptoms do not pass, refer to a doctor.

Patient with moderate to severe impairment

Since Cetirizine is mainly eliminated via renal route, in cases no alternative treatment can be used, the dosage intervals must be individualized according to renal function.

Group Creatinine clearance(ml/ min) Dosage and frequency
Normal ≥ 80 10 mg once daily
Mild 50 to 79 10 mg once daily
Moderate 30 to 49 5 mg once daily
Severe < 30 5 mg once daily every 2 days
End-stage renal disease

Patients undergoing dialysis

< 10 Contra-indicated

In pediatric patients suffering from renal impairment, the dose will have to be adjusted on an individual basis taking into account the renal clearance of the patients, his age and his body weight.

Patients with hepatic impairment: No dose adjustment is needed in patients with solely hepatic impairment.

Mode of Administration

  • Do not exceed the recommended dose
  • This medicine is not intended for children and infants below 2 years of age. 
  • You should use the measuring spoon, syringe or dropper designated for measuring the proper amount of medicine. If a measuring spoon or any other measuring device was not provided with the package, consult a pharmacist. 
  • Do not use a household teaspoon to measure the amount of medicine. Household teaspoons vary in their sizes and you may not receive the appropriate amount of medicine. 
  • Child-safety caps have significantly reduced the number of poisoning incidents caused by medicines each year. However, if you find it difficult to open the package, you can refer to a pharmacist to ask to have the safety mechanism removed and to turn the cap into a regular, easy to open cap. 
  • If you accidentally took a higher dosage, or if a child accidentally swallowed the medicine, immediately refer to a doctor or proceed to a hospital emergency room and bring the package of the medicine with you.
  • If you forgot to take this medicine at the required time, do not take a double dose. Take the next dose at the regular time and consult a doctor. 
  • Do not take medicines in the dark! Check the label and the dose each time you take medicine. Wear glasses if you need them.

If you have further questions regarding use of this medicine, consult a doctor or pharmacist.

SIDE EFFECTS

As with any medicine, use of Histazine may cause side effects in some users. Do not be alarmed when reading the list of side effects. You may not suffer from any of them.

Discontinue use and refer to a doctor immediately if the following effects develop:

  • Sudden signs of allergy such as: rash, itching. fever, swelling of the throat, face, lips, eyelids, tongue and/or other parts of the body, shortness of breath/difficulty breathing, anaphylactic shock.
  • Tendency to bruise and/or bleed more than usual.
  • Convulsions/fits (occurs rarely).
  • Restlessness, skin sensitivity to touch, drowsiness, stomach discomfort.
  • Headache, fatigue, dry mouth, dizziness. diarrhea in children, These effects occur often.
  • Weakness or malaise, diarrhea. These effects occur infrequently. 

Discontinue use and refer to a doctor if the following effects develop: 

Hallucinations, confusion. abnormal liver function results, rapid heart rate (occur rarely), fainting.

Additional side effects Occur frequently: 

  • Sore throat.
  • Nausea, abdominal pain.
  • Nosebleed.
  • Somnolence.
  • Cold-like symptoms of the nose (children only). 

Occur infrequently:

  • Nervousness. 
  • Insomnia. 
  • Numbness.
  • Blistering of the skin.
  • Rash and itching.
  • Tingling in the hands and feet.

Occur rarely:

  1. Edema. 
  2. Urticaria.
  3. Depression, aggression.
  4. Weight gain.
  5. Tremor, tics, muscle stiffness.
  6. Changes in sense of taste.
  7. Vision problems, such as blurred vision. 
  8. Difficulty/pain when passing urine, urinary incontinence.

If any of the side effects worsen or if you are suffering from a side effect not mentioned in this page, consult the doctor.

Side effects and drug interactions in children: Parents must report to the attending doctor all side effects and any additional medicine being given to the child.

Special warnings 

  • The use of Histazine syrup, is not recommended in children below 6 years of age suffering from kidney and/or liver function problems, due to lack of preparation safety information in this population.
  • Inform the doctor before taking this medicine if you are sensitive to any food or medicine.
  • Before doing any test to diagnose allergy, inform the doctor that you are taking this medicine, since taking this medicine can affect the results.
  • If you or your child are taking, or have recently taken, other medicines, including non-prescription medicines and nutritional supplements, tell the doctor or pharmacist. Especially, inform the doctor or pharmacist if you are taking: Medicines that affect the central nervous system such as: hypnotics and sedatives.

Do not use this medicine without consulting a doctor before commencing treatment if:

  • you are pregnant. 
  • you or your child are suffering from impaired function of the kidney/urinary system.
  • you or your child are suffering from epilepsy or are at increased risk for experiencing convulsions.
  • you or your child are suffering, or have suffered in the past, from impaired function of: the heart and/or blood vessels, the liver, the prostate, from emphysema or chronic bronchitis.
  • Do not drink wine or alcoholic beverages during the course of treatment with this medicine.
  • During use with this medicine side effects may appear (such as: drowsiness and fatigue) requiring caution when driving a car and when engaging in any activity that requires alertness.
  •  Children should be warned against riding a bicycle or playing near the road and the like.

Pregnancy and breastfeeding

  • If you are pregnant, consult a doctor or pharmacist before using this medicine.
  • Do not breastfeed while using this medicine.

Patient Information Leaflet

Cetirizine Syrup- Patient Information Leaflet
Cetirizine Syrup- Patient Information Leaflet

Categories and tags: R06AE07, Cetirizine, Piperazine derivatives, Syrup, Medicine intended for children from 2 to 6 years, Medicine intended for allergic condition, antihistamines for systemic use. Alternatives to this medicine: Cetralon, Zertazine, Zyrtec, Tomazine, Lergfree, Epirazine, Cetritin, Cetrak, Alerid, Histazine.

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