Fendol Capsules- Fendol D.S. Tablets:Mefenamic acid

COMPOSITION: Each Fendol D.S. tablet contains 500 mg Mefenamic Acid…. Each Fendol capsule contains 250 mg Mefenamic Acid.

Therapeutic indications

  1. As an anti-inflammatory and analgesic for the symptomatic relief rheumatoid arthritis, osteoarthritis, and pain including muscular, traumatic and dental pain, headaches.
  2. Post-operative and post-partum pain.
  3. Menstrual disorders (e.g. Primary dysmenorrhoea). 
  4. Menorrhagia due to dysfunctional causes and presence of an IUD when other pelvic pathology has been ruled out.
Fendol-DS - 500 mg mefenamic acid tablets
Fendol-DS – 500 mg mefenamic acid tablets


  • For oral administration Adults: 1 tablet (500mg) three times daily. 
  • In menorrhagia to be administered on the first day of excessive bleeding and continued according to the physician’s advice.
  • In dysmenorrhoea: To be administered at the onset of menstrual pain and continued according to the physician’s advice. 
  • Elderly (over 65 Years): As for adults. The elderly are at increased risk of the serious consequences of adverse reactions. If an NSAID is considered necessary, the lowest effective dose should be used and for the shortest possible duration
  • The patient should be monitored regularly for GI bleeding during NSAID therapy.
  • Fendol should be used with caution in elderly patients suffering from dehydration and renal disease. 
  • Children: It is recommended that children under 12 years of age should not be given Mefenamic Acid 500mg tablets. 
  • Fendol tablets should be taken preferably with or after food. 


  • Hypersensitivity to mefenamic acid or any of the other ingredients. 
  • Inflammatory bowel disease.
  • History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy.
  • Active, or history of recurrent peptic ulcer/haemorrhage. 
  • Severe heart failure, hepatic failure and renal failure.
  • Because the potential exists for cross-sensitivity to aspirin, ibuprofen, or other non-steroidal anti-inflammatory drugs, mefenamic acid must not be given to patients who have previously shown hypersensitivity reaction (e.g. asthma, bronchospasm, rhinitis, angioedema or urticaria) to these medicines.
  • During the last trimester of pregnancy. 
  • Treatment of pain after coronary artery bypass graft (CABG) surgery.


  • Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms.
  • Patients on prolonged therapy should be kept under regular surveillance with particular attention to liver dysfunction, rash, blood dyscrasias or development of diarrhoea.Appearance of any of these symptoms should be regarded as an !indication to stop therapy immediately. 
  • Prolonged use of any type of painkiller for headaches can make the worse. 
  • Precaution should be taken in patients suffering from dehydration and renal disease, particularly the elderly. 
  • Elderly: The elderly have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding and perforation which may be fatal.
  • Respiratory disorders: Caution is required if administered to patient suffering from, or with a previous history of bronchial asthma since NSAID have been reported to precipitate bronchospasm in such patients. 
  • Cardiovascular, Renal and Hepatic impairment: The administration of a NSAID may cause a dose dependant reduction in prostaglandin formation and precipitate renal failure.Patients at greatest risk of this reaction are those with impaired renal function, cardiac impairment, liver dysfunction, those taking diuretics and the elderly. Renal function should be monitored in these patients.
  • Female fertility: The use of mefenamic acid may impair female fertility and is not recommended in women attempting to conceive.
  • In dysmenorrhoea and menorrhagia lack of response should alert the physician to investigate other causes.
  • Epilepsy: Caution should be exercised when treating patients suffering from epilepsy.


Pregnancy: In view of the known effects of NSAIDs on the foetal cardiovascular system (risk of closure of the ductus arteriosus), use in the last trimester of pregnancy is contraindicated. The onset of labour may be delayed and the duration increased with an increased bleeding tendency in both mother and child. NSAIDs should not be used during the first two trimesters of pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus.

Lactation: Trace amounts of mefenamic acid may be present in breast milk and transmitted to the nursing infant. Therefore, mefenamic acid should not be taken by nursing mothers.

fendol - 250 mg mefenamic acid capsules
fendol – 250 mg mefenamic acid capsules


The most frequently reported side effects associated with mefenamic acid involve the gastrointestinal tract.

Diarrhoea occasionally occurs following the use of mefenamic acid. Although this may occur soon after starting treatment, it may also occur after several months of continuous use. The diarrhoea has been investigated in some patients who have continued this drug in spite of its continued presence. These patients were found to have associated proctocolitis. If diarrhoea does develop the drug should be withdrawn immediately and this patient should not receive mefenamic acid again.

Frequencies are not known for the following adverse reactions:

  • Blood and the lymphatic system disorders:  Haemolytic anaemia, anaemia, hypoplasia bone marrow, haematocrit decreased, thrombocytopenic purpura, temporary lowering of the white blood cell count (leukopenia) with a risk of infection, sepsis, and disseminated intravascular coagulation.
  • Immune system disorders: Hypersensitivity reactions have been reported following treatment with NSAIDs. These may consist of (a) non-specific allergic reactions and anaphylaxis (b) respiratory tract reactivity comprising asthma, aggravated asthma. bronchospasm, or dyspnoea or (c) assorted skin disorders including rashes of various types, pruritus, urticaria. purpura, angioedema, and more rarely exfoliative or bullous dermatoses.
  • Metabolism and nutritional disorders: Glucose intolerance in diabetic patients, hyponatraemia.
  • Psychiatric disorders: Confusion, depression, hallucinations, nervousness. 
  • Nervous system disorders: Optic neuritis, headaches, paraesthesia,  dizziness, drowsiness, reports of aseptic meningitis, Blurred vision, convulsions, insomnia. 
  • Eye disorders: Eye irritation, reversible loss of colour vision, visual disturbances.
  • Ear disorders: Ear pain, tinnitus, vertigo.
  • Cardiac and Vascular disorders:  Oedema. hypertension and cardiac failure have been reported in association with NSAID treatment. 
  • Respiratory, thoracic and mediastinal disorders:  Asthma, dyspnoea.
  • Gastrointestinal disorders: The most commonly observed adverse events are gastrointestinal in nature. Peptic ulcers, perforation or GI bleeding, sometimes fatal. particularly in the elderly.
  • Hepato-bilary disorders: Borderline elevations of one or more liver function tests, cholestatic jaundice, Hepatitis, hepatorenal syndrome.
  • Skin and subcutaneous tissue disorders: Angioedema, laryngeal oedema, erythema multiforme, face oedema, bullous reactions including Lyell’s syndrome and Stevens-Johnson syndrome, perspiration, rash, photosensitivity reaction, pruritus and urticaria. 
  • Renal and urinary disorders: Allergic glomerulonephritis, acute interstitial nephritis, dysuria, haematuria, nephrotic syndrome, proteinuria, renal failure including renal papillary necrosis.
  • General disorders: Fatigue, malaise, multi-organ failure, pyrexia.


For Arabic Information
Fendol- Arabic Information

Mefenamic acid – FAQ

Can I take Mefenamic Acid on an empty stomach? It is advisable to take Mefenamic Acid three times a day. If you are taking it for period pain, your doctor will likely suggest that you take it for a few days each month, starting on your first day of bleeding. Take mefenamic acid with food. This will help to protect your stomach from side-effects such as indigestion.

Is Mefenamic acid stronger than ibuprofen for period pain? Unlike ibuprofen or paracetamol which relieve inflammatory pain and can’t target areas, mefenamic acid does just work on the uterus. It has to be prescribed by a doctor, generally Mefenamic acid should be fine for any woman who has bad period pain that can not be controlled with normal painkillers.

How many times a day should I take mefenamic acid? Take mefenamic acid exactly as your doctor tells you to. The usual dose is 500 mg, which is taken as two 250 mg capsules, or one 500 mg tablet. You will be asked to take this dose three times a day.

Can I take antibiotic and mefenamic at the same time? Yes, you can. No interactions were found between amoxicillin or any other Antibiotic and mefenamic acid. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Is mefenamic acid good for back pain? It is used to relieve moderately severe pain, such as muscular aches and pains, menstrual cramps, headaches,back pain, and dental pain. Mefenamic acid relieves pain and inflammation as long as it is being taken, however it does not correct the cause of the pain.

Is mefenamic an antibiotic? No, it is not Antibiotic. Mefenamic acid is used for the short-term treatment of mild to moderate pain from various conditions. It is also used to decrease pain and blood loss from menstrual periods. Mefenamic acid is known as a nonsteroidal anti-inflammatory drug (NSAID).

How does mefenamic acid stop bleeding? Mefenamic acid and naproxen are only available on prescription. NSAIDs work by reducing your body’s production of a hormone-like substance called prostaglandin, which is linked to heavy periods. NSAIDs can also help relieve period pain. 

Which is better, mefenamic acid or paracetamol? The antipyretic efficacy of Mefenamic acid was more significant than Paracetamol (<0.05).Mefenamic acid was found to be more effective and equally tolerable than paracetamol as an antipyretic in pediatric patients with febrile illness and can be the best alternative to paracetamol.

Alternatives- Mefenamic Acid Products: Biostan forte tablets, Welstan Forte tablets, Mefex tablets, Kwnstan Forte tablets, Fenam Forte Tablets, Fenamic tablets, Fenamic tablets, Fenamol, Fendol,Mepestan, Mefenam, FAROSTAN FORTE, mefenamic plus tablets, Mefentan capsules, Mefpan D S tablets, Mefril,piostan lady tablet, Pono Forte, Ponstan& Ponstan Forte, Postamic,Mafepain,PONAGIC FORTEMEFRONIL.