Profenid Suppositories .. relieves pain- lowers fever- treats inflammation

What Profenid suppositories are? and what they are used for?

Ketoprofen 100 mg , the active ingredient in Profenid suppositories , is one of a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs reduce pain and inflammation. The intramuscular suppositories   is used to treat a number of painful conditions including:

  1. ‘Flare-ups’ of joint or back pain .
  2. Attacks of gout.
  3. Pain caused by kidney stones and biliary colic.
  4. Pain caused by injuries. 
  5. Analgesic for headache pain.
  6. Analgesic for dental pain.
  7. Calming menstrual symptoms and pain (menstrual pain).
  8. Antipyretic in fever.
  9. Analgesic for arthralgia.
  10. Analgesic for spine pain.
  11. Rheumatoid arthritis.
  12. Ankylosing spondylitis..
 Profenid Suppositories

Facts about Profenid suppositories

  • Profenid is an NSAID indicated for use in adults for the management of mild to moderate pain. 
  • Avoid use Profenid after 24 weeks gestation because this may affect the baby’s circulation.  
  • Nursing Mothers: Use Ketoprofen ( Profenid) with caution as Ketoprofen may be present/ secreted in human milk.
  • The usual adult dose is one or two suppositories (100 to 200 mg) each day for 5 – 7 days.
  • Your doctor may also prescribe another drug to protect the stomach to be taken at the same time with Profenid, particularly if you have had stomach problems before, or if you are elderly, or taking certain other drugs as well.
  • Your doctor will prescribe the lowest dose of Profenid for the shortest possible time, particularly if you are underweight or elderly.
  • Before taking Profenid, tell your doctor if you have kidney or liver problems.

How to take Profenid suppositories ?

  • The usual dose for this medicine is one suppository (100mg) at night, or twice aday (one in the morning and one at night).
  • Your doctor may have prescribed a different dose.
  • If required, Profenid capsules may also be taken during the day only as directed by your doctor.
  • Ask your doctor or pharmacist if you are unsure of the correct dose for you. They will tell you exactly how much to use.
  • Follow the instructions they give you. If you use the wrong dose, Profenid suppositories may not work as well and your problem may not improve.
  • How to use it:  Profenid suppositories should be inserted into the back passage at night.
  • Depending on your condition, you may need to use Profenid suppositories for a few days, a few weeks or for longer periods.
  • If you forget to use it: If it is almost time for your next dose, skip the dose you missed and take the next dose when you are meant to. Do not take a double dose to make up for the dose you have missed.

Common side effects

  • Stomach pain.
  • Heartburn.
  • nausea, vomiting.
  • Diarrhoea.
  • Indigestion.
  • Wind.
  • loss of appetite.
  • Headache.
  • Dizziness.
  • Vertigo.
  • Skin rash or spots.
  • Raised levels of liver enzymes in the blood.
  • suppositories   site reactions, symptoms include redness, swelling, change in the skin colour, inflammation, pain, and hypersensitivity. 

Things to consider before you start to take Profenid suppositories  

Some people MUST NOT have this suppositories  . Talk to your doctor if: 

  1. you think you may be allergic to Ketoprofen, aspirin, ibuprofen or any other NSAID, or to any of the other ingredients of Profenid suppositories . ( Signs of a hypersensitivity reaction include swelling of the face and mouth (angioedema), breathing problems, chest pain, runny nose, skin rash or any other allergic type reaction.
  2. you have now, or have ever had, a stomach (gastric) or duodenal (peptic) ulcer, or bleeding in the digestive tract (this can include blood in vomit, bleeding when emptying bowels, fresh blood in faeces or black, tarry faeces).
  3. you have had stomach or bowel problems after you have taken other NSAIDs.
  4. you have heart, kidney or liver failure.
  5.  if you have established heart disease and/or cerebrovascular disease e.g. if you have had a heart attack, stroke, mini-stroke (TIA) or blockages to blood vessels to the heart or brain or an operation to clear bypass blockages.
  6. if you have or have had problems with your blood circulation (peripheral arterial disease).
  7. you are more than six months pregnant.

You should also ask yourself these questions before having a Profenid suppositories , if the answer to any of these questions is YES, discuss your treatment with your doctor or pharmacist because Profenid suppositories might not be the right medicine for you. 

  • Do you suffer from any bowel disorders including ulcerative colitis or Crohn’s disease? 
  • Do you have kidney or liver problems, or are you elderly?
  • Do you suffer from any blood or bleeding disorder?
  • Do you have a condition called porphyria?
  • Have you ever had asthma? 
  • Are you breastfeeding?
  • Do you have angina, blood clots, high blood pressure, abnormally high levels of fat in your blood (raised cholesterol or raised triglycerides)? 
  • Do you have heart problems, or have you had a stroke, or do you think you might be at risk of these conditions (for example, if you have high blood pressure, diabetes or high cholesterol or are a smoker)?  
  • Do you have diabetes? 
  • Do you smoke? 
  • Do you have Lupus (SLE) or any similar condition?
  • Could you be suffering from dehydration? 
  • Have you suffered any heavy loss of blood recently? 

Are you taking other medicines?

Some medicines can interfere with your treatment. Tell your doctor or pharmacist if you are taking any of the following:

  1. Medicines to treat diabetes.
  2. Anticoagulants (blood thinning tablets like warfarin).
  3. Diuretics (water tablets).
  4. Lithium (used to treat some mental problems).
  5. Methotrexate (for some inflammatory diseases and some cancers).
  6. Cyclosporine and tacrolimus (used to treat some inflammatory diseases and after transplants).
  7. Trimethoprim (a medicine used to prevent or treat urinary tract infections).
  8. Quinolone antibiotics (for infections).
  9. Any other NSAID or COX-2 (cyclo-oxgenase-2) inhibitor, for example aspirin or ibuprofen.
  10. Mifepristone (a medicine used to terminate pregnancy).
  11. Cardiac glycosides (for example digoxin), used to treat heart problems.
  12. Medicines known as SSRIs used to treat depression.
  13. Oral steroids (an anti-inflammatory drug).
  14. Medicines used to treat heart conditions or high blood pressure, for example beta-blockers or ACE inhibitors. 
  15. Voriconazole (a medicine used to treat fungal infections). 
  16. Phenytoin (a medicine used to treat seizures) .
  17. Colestipol/cholestyramine (used to lower cholesterol) .

Always tell your doctor or pharmacist about all the medicines you are taking. This means medicines you have bought yourself as well as medicines on prescription from your doctor.

Profenid Suppositories and Pregnancy

Ketoprofen is a category (C) pregnancy drug. That means two things:

  • Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  • There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Are you pregnant or planning to become pregnant? Although not common, abnormalities have been reported in babies whose mothers have taken NSAIDs during pregnancy. You should not have a Profenid suppositories   during the last 3 months of pregnancy as it may affect the baby’s circulation.  

Are you trying for a baby? Having Profenid suppositories  may make it more difficult to conceive. You should talk to your doctor if you are planning to become pregnant, or if you have problems getting pregnant. 

Profenid Suppositories and Lactation

  • it isn’t known if ketoprofen passes into breast milk and causes harm to your child. You and your doctor may decide whether you’ll take ketoprofen or breastfeed.

Will there be any problems with driving or using machinery?

Very occasionally people have reported that Profenid suppositories have made them feel dizzy, tired or sleepy. Problems with eyesight have also been reported. If you are affected in this way, you should not drive or operate machinery. 

Other special warnings

  • You should take the lowest dose of Profenid for the shortest possible time, particularly if you are underweight or elderly.  
  • There is a small increased risk of heart attack or stroke when you are taking any medicine like Profenid. The risk is higher if you are taking high doses for a long time.  If at any time while taking Profenid you experience any signs or symptoms of problems with your heart or blood vessels such as chest pain, shortness of breath, weakness, or slurring of speech, contact your doctor immediately.  
  • If you have a history of stomach problems when you are taking NSAIDs, particularly if you are elderly, you must tell your doctor straight away if you notice any unusual symptoms. 
  • Because it is an anti-inflammatory medicine, Profenid may reduce the symptoms of infection, for example, headache and high temperature.
  • If you feel unwell and need to see a doctor, remember to tell him or her that you are taking Profenid.  
  • Profenid suppositories should not be used in children. 

Tell your doctor if you recently had or you are going to have a surgery of the stomach or intestinal tract before taking Profenid suppositories , as Profenid suppositories can sometimes worsen wound healing in your gut after surgery.

Overdose

ketoprofen

  • The symptoms of overdose are presented in individuals that consumed more than 300 mg/day.
  • Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.
  • May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (primarily in very young pediatric patients)            

Pharmacological Properties     

Pharmacodynamic properties: 

  • ketoprofen has analgesic, antipyretic actions and anti-inflammatory properties.
  • ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes (COX-1 and COX-2) and subsequent synthesis of prostaglandins and related compounds at peripheral sites within injured tissue.

Pharmacokinetic properties

  • Peak plasma ketoprofen concentration usually occurs between 0.5 to 2 hours after oral ingestion.
  • ketoprofen is distributed uniformly throughout most body fluids and 99% bound to plasma proteins.
  • Rapidly and extensively metabolized in the liver, primarily via conjugation to glucuronic acid. No active metabolites have been identified.
  • In a 24 hour period, approximately 80% of an administered dose of ketoprofen is excreted in the urine, primarily as the glucuronide metabolite.
  • The plasma half-life of ketoprofen after therapeutic doses is in the range of 1-4 hours for Conventional capsules, and 5.4 hours due to delayed absorption for Extended release (Sustained Release)(SR) capsules .   

Storage & Packaging  

    • Store ketoprofen tablets at room temperature from 68°F to 77°F (20°C to 25°C).
    • Keep this medication away from light.
    • Don’t store this medication in moist or damp areas, such as bathrooms..
For Arabic Information
Profenid suppositories .. Arabic Information

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