Urosolvine Effervescent Granules

For management of urolithiasis and gouty arthritis

للمعلومات عن يوروسولفين أكياس فوارة باللغة العربية / إضغط هنا

Composition

urosolvin sachet - composition and properties
urosolvin sachet – composition and properties

Each 5 g (sachet) contains: Active ingredients

  • Piperazine Citrate …0.1408 g ( To 0.128 g .Piperazine Hydrate).
  • Colchicine Crystals …0.3 mg.
  • Atropine Sulphate… 0.128 mg.

Inactive Ingredients: Sod.Bicarbonate ,Citric acid anhy., Tartaric acid, P.V.P, Lemon oil, Sucrose.

Properties

Pharmaceutical form: Effervescent Granules.

Pharmacotherapeutic group: Uricosuric.

Pharmacological action

An acute attack of gout apparently occurs as a result of increasing uric acid concentration that results in deposition of monosodium urate in the joint tissue.

urosolvin sachet - pharmacological properties
urosolvin sachet – pharmacological properties

 Piperazine known for many years to be an active drug in the treatment of gout and urinary lithiasis. It is claimed to increase the solubility of urates in the urine. It is relatively non- toxic.

 Colchicine gives rapid relief from pain in acute attacks of gout and the drug is specific for this condition to the extent that it can be used as a diagnostic agent in gout and gouty arthritis. Colchicine possesses anti-inflammatory properties. Although it is highly effective in treating acute gouty arthritis, it is not effective for other types of pain. It is not an analgesic and does not affect uric acid clearance. Instead,colchicine binds to proteins in microtubules of neutrophils. This binding in turn, inhibits the migration of neutrophils into the area of inflammation, thereby interfering with the inflammatory response to urate crystal deposition.

Atropine sulphate is added to relieve the spasm of the urinary tract.

Pharmacokinetics

 Urosolvine contains a typical uricosuric agent that promotes the urinary excretion of uric acid and thereby lower serum uric acid concentration.

Sodium citrate is an alkalinising agent since the citrate is converted into bicarbonate, alkaline urine is definitely more suitable for the excretion of urates in a more soluble form.

urosolvin sachet - kinetics, indications and dosage
urosolvin sachet – kinetics, indications and dosage

Indications

  • Acute and chronic gout .
  • Gouty arthritis .
  • For prophylaxis against urinary lithiasis ( urate stones).

Dosage and administration

  • In acute attack: one sachet dissolved in a half glass of water 6 times daily.
  • To prevent acute attack: 2 sachets dissolved in a glass of water 2 times daily.
  • As prophylaxis: 2 sachets dissolved In a glass of water once daily.

Contraindications

  1. Known hypersensitivity to any of the components of the drug.
  2. Blood dyserasias.
  3. Acute dehydration ,anuria or hyperkalemia.

Side effects

Occasionally nausea, vomiting,abdominal pain and diarrhea may occur.

urosolvin sachet - contraindications,side effects and while pregnancy
urosolvin sachet – contraindications,side effects and while pregnancy

Drug interactions

None.

Pregnancy and lactation

Contraindicated in pregnant women.

It is unknown if drug appears in breast milk.

Precautions and warnings

Used with caution in patients with serious GIT, renal, hepatic, and cardiovascular disorders.

It should not be used in children, geriatrics, debilitated patients and nursing women.

Package and storage

 Carton box of 12 Sachets X 5 g + inner leaflet.

Store at temperature not exceeding 25, in a dry place.

Instructions to patients

 Reduce dosage if vomiting or diarrhea occurs

Manufactured by El-NILE Co, for Pharmaceuticals andChemical Industries – Cairo – A.R.E.

Urosolvin Sachets .. Patient Information Leaflet

Urosolvin - patient information leaflet


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