For management of urolithiasis and gouty arthritis
للمعلومات عن يوروسولفين أكياس فوارة باللغة العربية / إضغط هنا
Composition
Each 5 g (sachet) contains: Active ingredients
- Piperazine Citrate …0.1408 g ( To 0.128 g .Piperazine Hydrate).
- Colchicine Crystals …0.3 mg.
- Atropine Sulphate… 0.128 mg.
Inactive Ingredients: Sod.Bicarbonate ,Citric acid anhy., Tartaric acid, P.V.P, Lemon oil, Sucrose.
Properties
Pharmaceutical form: Effervescent Granules.
Pharmacotherapeutic group: Uricosuric.
Pharmacological action
An acute attack of gout apparently occurs as a result of increasing uric acid concentration that results in deposition of monosodium urate in the joint tissue.
Piperazine known for many years to be an active drug in the treatment of gout and urinary lithiasis. It is claimed to increase the solubility of urates in the urine. It is relatively non- toxic.
Colchicine gives rapid relief from pain in acute attacks of gout and the drug is specific for this condition to the extent that it can be used as a diagnostic agent in gout and gouty arthritis. Colchicine possesses anti-inflammatory properties. Although it is highly effective in treating acute gouty arthritis, it is not effective for other types of pain. It is not an analgesic and does not affect uric acid clearance. Instead,colchicine binds to proteins in microtubules of neutrophils. This binding in turn, inhibits the migration of neutrophils into the area of inflammation, thereby interfering with the inflammatory response to urate crystal deposition.
Atropine sulphate is added to relieve the spasm of the urinary tract.
Pharmacokinetics
Urosolvine contains a typical uricosuric agent that promotes the urinary excretion of uric acid and thereby lower serum uric acid concentration.
Sodium citrate is an alkalinising agent since the citrate is converted into bicarbonate, alkaline urine is definitely more suitable for the excretion of urates in a more soluble form.
Indications
- Acute and chronic gout .
- Gouty arthritis .
- For prophylaxis against urinary lithiasis ( urate stones).
Dosage and administration
- In acute attack: one sachet dissolved in a half glass of water 6 times daily.
- To prevent acute attack: 2 sachets dissolved in a glass of water 2 times daily.
- As prophylaxis: 2 sachets dissolved In a glass of water once daily.
Contraindications
- Known hypersensitivity to any of the components of the drug.
- Blood dyserasias.
- Acute dehydration ,anuria or hyperkalemia.
Side effects
Occasionally nausea, vomiting,abdominal pain and diarrhea may occur.
Drug interactions
None.
Pregnancy and lactation
Contraindicated in pregnant women.
It is unknown if drug appears in breast milk.
Precautions and warnings
Used with caution in patients with serious GIT, renal, hepatic, and cardiovascular disorders.
It should not be used in children, geriatrics, debilitated patients and nursing women.
Package and storage
Carton box of 12 Sachets X 5 g + inner leaflet.
Store at temperature not exceeding 25, in a dry place.
Instructions to patients
Reduce dosage if vomiting or diarrhea occurs
Manufactured by El-NILE Co, for Pharmaceuticals andChemical Industries – Cairo – A.R.E.